![]() ![]() Their use in veterinary medicine and human medicine is a trade-off of benefit versus risk. All legitimate medications come with their own risks. When the inflammatory cascade is blocked at such a high level, your pet’s defenses against cancer, and infection are decreased as well. But it works at such a high level in the itch cascade (open the diagram at the top of this page) that it also interferes with a lot of important positive defenses that Nature designed your dog’s immune system to perform. It would be a superb drug – if it did only that. The medication short circuits your pet’s “misinformed” immune system that has mistaken harmless organic things in our environment such as pollen for things that might be dangerous if they invaded its body. What Are The Differences Between Cytopoint® And Apoquel®?Īpoquel® tablets bring dramatic relief to most dogs who suffer from skin allergies. They are Librela® for dogs and Solensia® for cats. Zoetis’ most recent entries in the field are aimed at controlling arthritic pain. They either “caninized” the drug or “felinized” it so your pet’s immune system will accept them. Nexvet had figured out an ingenious way to quickly convert new human monoclonal antibody biologicals to work in dogs or cats. Subsequently, Zoetis purchased the only competing company in that business, a small Irish firm called Nexvet. That follows the same trend occurring in human medicine today – the use of large, complex, bioengineered antibodies ( read here) instead of smaller molecule drugs (like Apoquel®) to treat complex diseases. Zoetis also saw Cytopoint® as a great entry door into the precision drug market for animals. They hoped that Cytopoint®, which is thought to target only a single signaling compound responsible for itch and inflammation, IL-31, would be more precise in its actions. ![]() The Company realized that Apoquel®, because of its broader action, had more potential to produce unwanted side effects. It was unclear why Zoetis planed to market two competitive drugs to treat the same condition. The USDA approved Cytopoint®, and should be monitoring it because it is considered a biological. The FDA approved and monitors its “cousin”, Apoquel® because it is considered a drug. When I began this article on Cytopoint® ( lokivetmab), Zoetis hadn’t gotten around to naming it yet – just called it CADI. Which Is More Effective – Can I Use Both? – Do I have Other Options? Ron Hines DVM PhD Cytopoint® Versus Apoquel® For My Itchy Dog – Which Is Safer – ![]()
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